Elucidating the cause of FAT10 over-expression in liver and colon carcinomas

Acknowledgments First of all, I would like to thank Prof. Dr. Marcus Groettrup for giving me the opportunity to do this work in his lab, where I began as a diploma student. He provided me with important advice and constant support during my work. Many thanks also go to … Gunter Schmidtke, who was always open to give me advice, not only in biochemical terms My fellow PhD students on the FAT10 project, especially Birte Kalveram, Christiane Pelzer, Kathrin Kluge and our " Pretty Queen " Neha Rani for a lot of fun in the lab Marc Müller and Annette Sommershof for nice coffee breaks on the roof and beer at " Klimperkasten " My dear friend Khalid, a constant source of high spirits and amusement, who taught me some " nice " Hindi words All my colleagues in the Groettrup lab, who made the time that I spend here really enjoyable!! Gerardo for making great Caipirinha's during fantastic lab parties. Elmar Spies for many, many hours on our road bikes, his delicious Käßspätzle and for " The Pump " Peter Öhlschläger, for being an extraordinary person and friend I am really grateful to Anja Holtz, for pleasant coffee breaks, her delicious cakes and many stimulating discussions on any topic. I am also very thankful to Christopher, for being my friend since the first day in Konstanz! Najbardziej chciałbym podziekować mojej rodzinie, która zawsze we mnie wierzyła i mi pomagała jak tylko mogła.